VIP Activates and Couples Clock Cells. Focus on “Disrupted Neuronal Activity Rhythms in the Suprachiasmatic Nucleus of Vasoactive Intestinal Polypeptide-Deficient Mice” by
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Disrupted neuronal activity rhythms in the suprachiasmatic nuclei of vasoactive intestinal polypeptide-deficient mice.
Vasoactive intestinal polypeptide (VIP), acting via the VPAC(2) receptor, is a key signaling pathway in the suprachiasmatic nuclei (SCN), the master clock controlling daily rhythms in mammals. Most mice lacking functional VPAC(2) receptors are unable to sustain behavioral rhythms and lack detectable SCN electrical rhythms in vitro. Adult mice that do not produce VIP (VIP/PHI(-/-)) exhibit less ...
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Abstract Vasoactive Intestinal Polypeptide (VIP), has been found in different neurotransmitter systems and exists in various nerve tracts in the brain. Potential role of this peptide in physiological processes such as regulation of sleep and wakefulness, and biological rhythms has been confirmed in several reports. In the present research effects of intracerebroventricular (ICV) injection of a...
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Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and use intercellular signaling to synchronize their timekeeping activities so that the SCN can coordinate brain physiology and behavior. The neuropeptide vasoactive intestinal polypeptide (VIP) and its VPAC2 receptor form a key component of intercellular signaling systems in the SCN and critically c...
متن کاملGastrin-releasing peptide promotes suprachiasmatic nuclei cellular rhythmicity in the absence of vasoactive intestinal polypeptide-VPAC2 receptor signaling.
Vasoactive intestinal polypeptide (VIP) and gastrin-releasing peptide (GRP) acting via the VPAC2 receptor and BB2 receptors, respectively, are key signaling pathways in the suprachiasmatic nuclei (SCN) circadian clock. Transgenic mice lacking the VPAC2 receptor (Vipr2(-/-)) display a continuum of disrupted behavioral rhythms with only a minority capable of sustaining predictable cycles of rest ...
متن کاملVIP activates and couples clock cells. Focus on "Disrupted neuronal activity rhythms in the suprachiasmatic nucleus of vasoactive intestinal polypeptide-deficient mice".
Neurons of the suprachiasmatic nucleus (SCN), located in the ventromedial hypothalamus, comprise the central mammalian circadian pacemaker (Reppert and Weaver 2002). In dispersed culture, these neurons can generate autonomous circadian (ca. 24 h) oscillations in spontaneous firing rate (Welsh et al. 1995). In vivo, they are normally synchronized to the 24 h light/dark cycle by input from the re...
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